A grant of €63,506 has been awarded to the North West Alcohol Forum for the 11 month ‘Donegal Reach’ Project.The project is working with up to twelve 14-16 year-olds across Donegal affected by parental alcohol or other drug use.The overall aim of the project is to build up young people’s self-esteem, promote positive relationships, help them to become more resilient and improve their future prospects. The grant is part of an International Fund for Ireland pledge of €2,805,315 to provide further intervention and support for marginalised communities.The latest funding allocation will support 23 projects in their peace and reconciliation work across the southern border counties and Northern Ireland.A significant proportion of funding will focus on the Fund’s Personal Youth Development Programme (PYDP).Launched in 2015, the programme works with 16-25 year olds who have faced a range of complex issues including; poor mental health, substance abuse, homelessness, difficult family backgrounds and been in or close to the criminal justice system. Commenting on the latest funding package, IFI Chairman, Paddy Harte said he IFI’s work is more relevant than ever.He said “The continued lack of political leadership alongside an increase in hard line opinions on Brexit and dissident activity means that many communities feel more isolated and entrenched with little support on the ground to deliver positive outcomes.“The IFI is delivering interventions and prepared to go where other agencies cannot to offer better pathways for engagement and growth. Our PYDP programme in particular is like no other youth initiative. It is tailored to the individual, develops much needed life skills, instils confidence and prepares young people for positive life choices and employment.”The IFI’s Personal Youth Development Programme has engaged with over 1800 young people with 3278 accreditations received, 528 progressing into education and training with 390 securing employment.North West Alcohol Forum based in Letterkenny has received €63,506 for its ‘Donegal Reach’ Project, working with 14-16 year olds across Donegal affected by parental alcohol or other drug use. It aims to build up young people’s self-esteem, promote positive relationships, help them to become more resilient and improve their future prospects.Mr Harte adds: “Young people today face more challenges than ever and they often feel that society has let them down.“Growing tensions within communities alongside high levels of social and economic deprivation all work hand in hand to spur on those opposed to the Peace Process who continue to try and radicalise young people through paramilitary recruitment.“We will continue to engage with those who have benefited little from the Good Friday Agreement and help young people to transform and become positive role models within their local communities.” The Chairman took the opportunity to thank the international donors to the Fund – the European Union and the Governments of the United States of America, Canada, Australia and New Zealand – for their support.More than €63K for underage alcohol and drug programme in Donegal was last modified: December 9th, 2019 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:alcoholdrugsgrantIFIpaddy harte
A former woman assistant professor of IIM-Rohtak has accused the institute’s director, Dheeraj Sharma, of sexually harassing her and seeking sexual favours.A case has been registered against the director at Rohtak’s women police station on charges of assault to outrage the modesty of a woman and making sexually coloured remarks.The 35-year-old complainant told the police that Prof. Sharma began sexually harassing her soon after her appointment to the post of assistant professor on September 1 last year on a probation period of three years. She was dismissed from service on May 10, almost a month after she complained about Prof. Sharma’s behaviour to the institute’s board.She alleged in the FIR that the director would make indecent remarks on her private life, looks and clothes. She further alleged that he would ask her out for evening strolls and even groped her inside her cabin on one occasion.Women’s police station SHO Garima said the FIR in the case was registered on May 29. “Prof. Sharma is yet to join the investigation. But the IIM authorities told us that they had already informed the area police station expressing apprehension that the assistant professor might level false allegations against the faculty after she had been dismissed,” said Ms. Garima.Speaking to The Hindu, the complainant said long before going to the police she had written to the IIM board’s chairman, the HRD Ministry and even the Prime Minister’s Office, but there was no response. She alleged that the director continued to put pressure on her to withdraw the complaint and when all his efforts failed, he sacked her without “assigning any reason”.IIM-Rohtak in an official communication said that the complainant was terminated a month ago and “she is doing this to defame the director and the institute”.
La Liga champions Real Madrid suffered a shock 2-1 defeat in their first ever league visit to Catalan side Girona on Sunday, conceding two goals in quick succession and falling eight points behind leaders Barcelona.Spain midfielder Isco tapped in a rebounded shot from Cristiano Ronaldo to open the scoring in the 12th minute in Real Madrid’s first visit to Catalonia this season amid the worst political crisis in Spain’s 39 years of democracy.The home side struck the woodwork twice before the break but rallied in the second half and Uruguay international Christian Stuani fired them level in the 54th minute.Stuani’s record v Real Madrid2012/13 (Espanyol) ??? ??2014/15 (Espanyol) ??? ??2017/18 (Girona) ??? ??#GironaRealMadrid pic.twitter.com/tjAKxqu3dT- LaLiga (@LaLigaEN) October 29, 2017Forward Portu then turned in the winning goal four minutes later to the delight of the 13,500 fans crammed into the Montilivi stadium.Stuani came within inches of scoring again midway through the second half but a one-goal advantage was enough to give Girona their third win in their first campaign in the top flight and inflict a second league defeat on Zinedine Zidane’s side.Real are third in the standings on 20 points, four behind second-placed Valencia while unbeaten leaders Barca have 28.Although Real Madrid have many supporters in Catalonia, they are viewed as the club that most representative of Spain and the arrival of the team bus at Montilivi was greeted with a smattering of boos and pro-Catalan independence flags.The political heat intensified two days before their visit when the region’s ruling party declared independence from Spain and the central government responded by dissolving the Catalan parliament.advertisementDeposed president Carles Puigdemont is from Girona province but did not make an appearance, despite reports he would be in the presidential box as he was for the game with Barcelona in September.Despite the political undertones, the atmosphere was no more intimidating for Madrid than any other Liga ground and they were cheered on by hundreds of supporters who mixed with the home fans without any trouble.Pablo Maffeo, the Manchester City loanee who gained fame for his man-marking job on Lionel Messi, provided the first flash point of the game when his searching cross from the right wing pinged off the far post.The ball remained in play and Madrid surged up the other end where Ronaldo fired at Girona goalkeeper Yassine Bounou and Isco was ideally placed to tap in the rebound.Girona’s fighting spirit could not be crushed, however, and they staged an incredible turnaround to record arguably the most significant win in their 87-year history..@GironaFC’s record v Real Madrid in #LaLigaSantander…played 1 won 1! #GironaRealMadrid 2-1 pic.twitter.com/1XQbGnAhXa- LaLiga (@LaLigaEN) October 29, 2017
SAN JOSE, Calif. — Henrik Lundqvist is playing like an All-Star, even if he’s not recognized as one.Lundqvist made 30 saves just hours after getting passed over for the All-Star game and the New York Rangers completed a rare California sweep by beating the San Jose Sharks 3-1 on Jan. 10. night.“I want to be one of those guys, obviously,” Lundqvist said. “I see myself as a guy that can compete against the guys that are there. At the same time, there’s a lot of guys having a strong season right now. For me, it’s more important to get the results right now.”Chris Kreider scored one goal and set up Martin St. Louis for another for the Rangers, who have 13 wins in 14 games for the first time since 1973.That includes wins in a four-day span at Anaheim, Los Angeles and San Jose — the first time New York has even beaten those three teams on the road in the same season.Rick Nash added an empty-net goal to seal it.“It was a great answering of the bell,” Nash said. “We talked about it for the three days before we came out here that this was going to be a gritty task and I thought we played great. It’s impressive to get these three wins. At the same point, it’s just three wins.”Melker Karlsson joined Jeff Friesen as the only Sharks rookies to score goals in five straight games when he converted on the power play in the third period. Antti Niemi made 28 saves.Even the return of Joe Thornton couldn’t help the Sharks, who were coming off a second 7-2 loss to St. Louis in a six-day span. Thornton missed four games with a shoulder injury and the power play looked impotent in his absence with one goal on 19 attempts.San Jose looked sharp on its first power play against the Rangers in the first period, but couldn’t get anything past Lundqvist, who responded to his All-Star game snub by reaching 20 wins for a 10th straight season.That’s the way it went for most of the night as Lundqvist was outstanding, including getting a piece of Joe Pavelski’s shot from alone in the slot midway through the second to keep the game 2-0.“We didn’t finish our chances,” Pavelski said. “We played hard, but it came down to a couple of things, execution on certain things.”The Rangers missed a chance to add to the lead early in the third when Niemi made a spectacular glove save along the goal line to rob Mats Zuccarello. The play went under a lengthy replay review before being upheld to the dismay of the Rangers.“Pucks in the mitt, mitt’s in the net,” Rangers coach Alain Vigneault said. “I’ll let you use your common sense.”The Sharks then converted on the power play just minutes later when Karlsson knocked in a rebound of James Sheppard’s shot for the Sharks’ lone goal.The game marked the return to San Jose for defenseman Dan Boyle, who became the franchise’s career leader in points by a defenseman in his six years with the Sharks.Boyle got a bloody nose on his opening shift and had to go to the locker room. But he was back later in the first for a video tribute that was followed by a long ovation and stick tapping from both teams.“It was an amazing moment,” he said. “It was just a minute long, but that’s going to stay with me for a lifetime.”The Rangers took nearly 10 minutes to get their first shot on goal, but still ended up ahead 2-0 after the first period when they scored after faceoffs in the offensive zone.Kreider set up the first when he tapped a loose puck to St. Louis, who knocked it in from the slot to make it 1-0.Later in the period, Kreider tipped a shot by Dan Girardi on goal after a faceoff win by Stepan and then tapped in the rebound.(JOSH DUBOW, AP Sports Writer)TweetPinShare0 Shares
Real Madrid striker Benzema unimpressed by L’Equipeby Carlos Volcano10 months agoSend to a friendShare the loveReal Madrid striker Karim Benzema is unimpressed by L’Equipe ignoring his work in 2018.The striker failed to make the top 15 strikers list, which featured fellow Frenchman Antoine Griezmann and former Real Madrid teammate Cristiano Ronaldo, yet Benzema took the news relatively well as he made a joke out of the situation.”L’Equipe, my friends, can I be the 16th?” he wrote on Instagram.Benzema on the paper’s 2018 best strikers shortlist: “L’Equipe, my friends, can I be the 16th?Should’ve just let it go ma man pic.twitter.com/wlaZL4aOiT— (@Ultra_Suristic) January 4, 2019 About the authorCarlos VolcanoShare the loveHave your say
Twitter You can take the boy out of Canada but you can’t take Canada out of the boy. When I meet with Brampton, Ont.-born Michael Cera to chat about his new project, The Lego Batman Movie, he’s having lunch, eating a Waldorf salad. The 28-year-old began his career in Canada with a Tim Hortons summer camp commercial before decamping to the United States, finding fame with Arrested Development and a string of successful movies like Superbad and Juno, but has retained his disarming Canadian politeness. I walk in, he jumps up, “Do you want anything? Cheese? A coffee? How are you doing?” Facebook Advertisement LEAVE A REPLY Cancel replyLog in to leave a comment Login/Register With: Advertisement Advertisement
Reviewed by James Ives, M.Psych. (Editor)Dec 20 2018Machine learning is the study of algorithms and statistical models that computer systems use to progressively improve their performance on a specific task. It is clearly visible that, machine learning is essential in this era in which we are living in, when there is huge amount of epigenetic data present coming from experiments and the clinic. Machine learning can aid in detection of epigenetic features in a given genome. Machine learning also helps in finding similarities and relationships between phenotypes and modifications in histones and genes. It also helps to accelerate the screening of lead compounds which are targeting markers for epigenetics diseases. Along with these uses, there are many other aspects around the study on epigenetics, which consequently bring us closer to realize our current hopes in precision medicine. Many new studies in precision medicine targeting epigenetic disease biomarkers are therefore now possible because of the fact that machine learning algorithms have accelerated processes used for data analyses. Therefore, in order to take full benefit of machine learning algorithms, one should get familiar with the pros and cons of them as it is one way to bring optimum use out of them.In this review, the authors discuss the fundamentals and the important points of machine learning, the applications of machine learning, the methods which are used in the field of epigenetics and their features. The advantages and disadvantages of using machine language for research in epigenetics are also discussed.Source: https://benthamscience.com/
Source:https://www.nrgoncology.org/News/Research-Results/High-dose-Stereotactic-Body-Radiotherapy-Well-tolerated-by-Patients-with-Centrally-Located-Lung-Tumors Reviewed by Kate Anderton, B.Sc. (Editor)Apr 5 2019Stereotactic Body Radiotherapy (SBRT), a high-dose, precisely delivered radiotherapy, is considered the standard treatment for patients with medically inoperable, node-negative, non-small cell lung cancer (NSCLC). However, this well-tolerated radiation treatment was not previously tested in centrally located NSCLC due to the fact that patients with centrally located lung tumors demonstrate a higher risk for toxicity if treated with high SBRT doses.The NRG Oncology clinical study NRG-RTOG 0813 was designed to find the maximum tolerated dose (MTD) of SBRT for centrally located NSCLC in medically inoperable patients. The seamless Phase I/II study examined a 5 fraction, dose escalating schedule of SBRT that ranged from 10 to 12 Gy/fraction delivered over 1.5 to 2 weeks in 120 accrued patients from the United States and Canada. Results of this study are published in the Journal of Clinical Oncology.Related StoriesAdult survivors of pediatric brain tumors may experience cognitive, socioeconomic burdensRadiation associated with increased risk of adverse cardiac events in lung cancer patientsStudy shows both IDH-mutant WHO-defined molecular subgroups could benefit from PCV chemoradiotherapyThe MTD was the highest dose level allowed by the protocol, 12.0 Gy per fraction in 5 fractions, and was associated with a 7.2% dose-limiting toxicity (DLT), defined as any treatment-related grade 3 or worse from a list of predefined toxicity types which occurred within the first year. The DLT rate of 7.2% is significantly below the protocol-specified target rate of 20%. Treatment was also associated with high rates of tumor control.”The patients who enrolled into NRG-RTOG 0813 were medically inoperable with early stage lung cancer, mostly elderly and with co-morbidities. The two-year overall survival rates for patients at the two highest doses were 70% which is comparable to patients with peripheral early stage tumors that were treated by SBRT,” stated Andrea Bezjak, MD, of the Princess Margaret Cancer Center and the lead author of NRG-RTOG 0813.Two-year rates for the 71 evaluable patients in the 11.5Gy/fr and 12.0Gy/fr cohorts were: local control 89.4% (90% CI:81.6-97.4), 87.9% (90% CI :78.8-97.0); overall survival 67.9% (95%:50.4-80.3), 72.7% (95%:54.1-84.8); progression-free survival 52.2% (95%:35.3-66.6), 54.5% (95%:36.3-69.6).”This trial demonstrated our ability to provide local control and potential for cure in patients with centrally located, node-negative tumors in multiple institutions, while maintaining plan qualities, achieving good patient outcomes, and only allowing modest rates of toxicity,” added Dr. Bezjak.
By Sally Robertson, B.Sc.Jun 14 2019Reviewed by Kate Anderton, B.Sc. (Editor)A warning from the U.S Food and Drug Administration (FDA) was issued yesterday after a patient died due to receiving a fecal transplant that contained drug-resistant bacteria. Such transplants are carried out to treat the infection Clostridium difficile (C. difficile) in patients who have failed to respond to standard treatments.Kateryna Kon | ShutterstockRecurrent C. difficile infections are caused by overgrowth of the microbe, which occurs when the normal composition of the gut microbiome becomes disrupted (dysbiosis) by the administration of antibiotics. Typically, the treatment approach is the use of long-term antibiotics. However, recurrence is common and the infection can be debilitating and lead to significantly reduced quality of life and poor health.Fecal transplants provide an alternative to antibioticsA fecal transplant involves slightly processed feces from a healthy person being transferred to the infected person’s gut to introduce beneficial or “friendly” bacteria. The procedure is intended to restore a diverse and stable gut microbiome that is in keeping with what would be considered a healthy bowel.A fecal transplant provides a more favorable combination of microbial species and strains that complements and replaces a microbiome that has become imbalanced. This restores stability, with the resulting microbiome comprised of all the necessary microorganisms.The only currently approved application of fecal transfer is in the treatment of recurrent C.difficile that continues after standard antibiotic treatment has been used. When the fecal transplant is used, relapse rates are significantly reduced.How do fecal transplants help patients overcome C. difficile infections?The gut microbiota is become increasingly important to researchers who have been discovering more and more about how it functions and contributes to bodily health.A disturbed gut microbiome can contribute to a number of chronic gut disorders and metabolic conditions such as diabetes and obesity. In this context, fecal transfer has emerged as promising approach to restoring a healthy gut microbiome in order to treat diseases of the gut. Evidence has previously demonstrated absolute efficacy when the approach is used to treat recurrent C. difficile.However, there are still questions surrounding the issues of safety and best practice. As interest in the benefits of fecal transplant grows, the potential need for better regulation is being brought to the fore.The FDA reportThe FDA reports that two adult patients with compromised immune systems who had transplants from the same donor became heavily infected with Escherichia coli (E.coli) that produces enzymes called extended-spectrum beta-lactamase (ESBL).Bacteria that produce ESBLs are resistant to many antibiotics including penicillin and cephalosporin. The ESBLs most commonly produced by E.coli are called CTX-M enzymes. When E.coli produces ESBLs, urinary tract infections develop that can lead to more serious infections such as septicemia, which can be fatal.When E.coli produces ESBLs and is therefore resistant to drugs, the infection becomes much more difficult to treat.The FDA says the stool was not checked for the presence of drug-resistant bacteria before the procedure. This only happened once the patients became ill, when a stored sample was tested and found to contain the resistant E.coli that had infected both patients.The failing in procedure has triggered the FDA to state that all potential donors must be screened from now on with questions and stool tests for drug-resistant bacteria.According to the Centers for Disease Control and Prevention (CDC), C. difficile causes almost half a million illnesses annually and can affect all age groups. The CDC also refers to antibiotic resistance as one of the largest public health threats we face today.One report by the CDC found that in the U.S., at least two million individuals acquire drug-resistant infections, which results in death in at least 23,000 cases.
By Angela Betsaida B. Laguipo, BSNJun 26 2019A portable device attached to a smartphone can help capture precise images of the retina to diagnose eye disease. The new method by a startup company, Phelcom Technologies, is a lower cost tool that can help doctors diagnose remotely, through telemedicine.The FAPESP’s Innovative Research in Small Business Program (PIPE) granted funding and support for Phelcom in 2016. With the grant, the team needed to develop a prototype, which has recently won funding for manufacture and commercialization of the device. Aside from the grant, the Albert Einstein Jewish-Brazilian Charitable Society (SBIBAE) has invested in Phelcom. Phelcom Eyer An app operating the optical device sends images of the retina over the internet to Eyer Cloud, which stores and manages patient files. Image Credit: Phelcom Technologies The device, called Eyer, is designed to light up and visualize the retina. It is connected to a smartphone’s camera. An application sends the captured images over the internet via the Eyer Cloud, which stores the patient files. The ophthalmologist can view the images remotely through the cloud by accessing the patient files.Due to lack of internet connection in some areas across the globe, the images are kept in the smartphone app and sent to the cloud when an internet connection, either Wi-Fi or 4G network is available. Help diagnose retinal eye diseasesThe new device can help diagnose eye diseases, particularly those affecting the retina. The retina is the light-sensing tissue found in the back of the eye. One of its roles is to relay images to the brain.Back-of-the-eye or fundus eye diseases include conditions such as Stargardt’s disease, macular degeneration, retinal tear, diabetic retinopathy and retinal detachment, among others. Stargardt’s disease refer to a group of inherited diseases that affects the light-sensitive cells in the retina to deteriorate. Macular degeneration is a condition where the center of the retina deteriorates, leading to blurred central vision or a blind spot. Retinal tear happens when the vitreous, or gel-like substance in the center of the eye shrinks, pulling the thin layer of tissue lining in the retina, causing a tissue break. Diabetic retinopathy can cause blindness in people with diabetes. It happens when the blood sugar shoots up, causing damage to the blood vessels supplying the retina.The Eyer ProjectRelated StoriesEarly clinical trial of new treatment for severe dry eye disease shows promising resultsDeveloping imaging techniques for early detection of eye and brain diseasesProtein found in the eye can protect against diabetic retinopathyIn March, Phelcom established its São Carlos factory after getting a certification from the National Health Surveillance Agency (ANVISA) and the National Institute of Metrology, Quality and Technology (INMETRO).The factory manufactures 30 units a month but is projected to reach about 100 units by the end of 2019. The device is priced at $5,000, accompanied by a high-quality smartphone. The device is way cheaper than conventional equipment. The currently-used ophthalmoscope device has to be connected to a computer to capture images and it costs around $30,000. “We invested significantly in optics and in design. One challenge was producing a portable version of a device that is typically very large. Another was enabling nonmydriatic operation so that high-quality images of the retina can be captured without the need for pupil dilation,” José Augusto Stuchi, Phelcom CEO, said in a statement.The Eyer CloudThe company has also developed the Eyer Cloud, an innovation designed to store and manage all the data, including patient information and retinal images, acquired in the diagnostic test. The software works by organizing data, so doctors can remotely access for diagnosis.In contrast, current equipment used today needs to be attached to a computer. The Eyer is portable, easier to use, and more accessible. To set up the Eyer and its cloud, the user should create an account, where the images can be automatically saved.The researchers assured that all data are kept private and confidential. Also, they worked on making the transmitting of images from the device to the cloud faster, so doctors can access the images regardless of the device’s location.The device uses telemedicine, since a licensed or trained technician uses the device to capture the images and sends the photos to the cloud. Meanwhile, an ophthalmologist can visualize and analyze the photos in another location. The process makes diagnosing faster and more convenient.At present, the company plans to establish a partnership with ophthalmologists to develop a part of the system responsible for reporting. For doctors, the planned payment is by a monthly subscription and each report will roughly cost about $5 to $10.Artificial intelligenceAside from the cloud, the team is working on artificial intelligence to help in finding patterns, detecting diabetic retinopathy. The medical reports will be placed in a database, where the computer uses AI to find patterns linked to retinal diseases.A software, approved by the U.S. Food and Drug Administration (FDA), called IDx-DR, utilizes AI to examine eye images captured by a retinal camera. These images will be analyzed to detect diabetic retinopathy, potentially diagnosing the condition early to prevent blindness.The company has more than 10,000 images of the retina and projects about 50,000 patients next year. They plan to have the largest database across the globe. Source:http://pesquisaparainovacao.fapesp.br/portable_device_can_be_used_to_diagnose_eye_disease_remotely/1074