10 months agoReal Madrid striker Benzema unimpressed by L’Equipe

first_imgReal Madrid striker Benzema unimpressed by L’Equipeby Carlos Volcano10 months agoSend to a friendShare the loveReal Madrid striker Karim Benzema is unimpressed by L’Equipe ignoring his work in 2018.The striker failed to make the top 15 strikers list, which featured fellow Frenchman Antoine Griezmann and former Real Madrid teammate Cristiano Ronaldo, yet Benzema took the news relatively well as he made a joke out of the situation.”L’Equipe, my friends, can I be the 16th?” he wrote on Instagram.Benzema on the paper’s 2018 best strikers shortlist: “L’Equipe, my friends, can I be the 16th?Should’ve just let it go ma man pic.twitter.com/wlaZL4aOiT— (@Ultra_Suristic) January 4, 2019 About the authorCarlos VolcanoShare the loveHave your saylast_img read more

Cera still Canadian to his core as he dons his superhero cape

first_img Twitter You can take the boy out of Canada but you can’t take Canada out of the boy. When I meet with Brampton, Ont.-born Michael Cera to chat about his new project, The Lego Batman Movie, he’s having lunch, eating a Waldorf salad. The 28-year-old began his career in Canada with a Tim Hortons summer camp commercial before decamping to the United States, finding fame with Arrested Development and a string of successful movies like Superbad and Juno, but has retained his disarming Canadian politeness. I walk in, he jumps up, “Do you want anything? Cheese? A coffee? How are you doing?” Facebook Advertisement LEAVE A REPLY Cancel replyLog in to leave a comment Login/Register With: Advertisement Advertisementlast_img read more

Fundamentals applications and methods of machine learning used in epigenetics

first_imgReviewed by James Ives, M.Psych. (Editor)Dec 20 2018Machine learning is the study of algorithms and statistical models that computer systems use to progressively improve their performance on a specific task. It is clearly visible that, machine learning is essential in this era in which we are living in, when there is huge amount of epigenetic data present coming from experiments and the clinic. Machine learning can aid in detection of epigenetic features in a given genome. Machine learning also helps in finding similarities and relationships between phenotypes and modifications in histones and genes. It also helps to accelerate the screening of lead compounds which are targeting markers for epigenetics diseases. Along with these uses, there are many other aspects around the study on epigenetics, which consequently bring us closer to realize our current hopes in precision medicine. Many new studies in precision medicine targeting epigenetic disease biomarkers are therefore now possible because of the fact that machine learning algorithms have accelerated processes used for data analyses. Therefore, in order to take full benefit of machine learning algorithms, one should get familiar with the pros and cons of them as it is one way to bring optimum use out of them.In this review, the authors discuss the fundamentals and the important points of machine learning, the applications of machine learning, the methods which are used in the field of epigenetics and their features. The advantages and disadvantages of using machine language for research in epigenetics are also discussed.Source: https://benthamscience.com/last_img read more

Highdose standard radiation treatment welltolerated by patients with centrally located NSCLC

first_img Source:https://www.nrgoncology.org/News/Research-Results/High-dose-Stereotactic-Body-Radiotherapy-Well-tolerated-by-Patients-with-Centrally-Located-Lung-Tumors Reviewed by Kate Anderton, B.Sc. (Editor)Apr 5 2019Stereotactic Body Radiotherapy (SBRT), a high-dose, precisely delivered radiotherapy, is considered the standard treatment for patients with medically inoperable, node-negative, non-small cell lung cancer (NSCLC). However, this well-tolerated radiation treatment was not previously tested in centrally located NSCLC due to the fact that patients with centrally located lung tumors demonstrate a higher risk for toxicity if treated with high SBRT doses.The NRG Oncology clinical study NRG-RTOG 0813 was designed to find the maximum tolerated dose (MTD) of SBRT for centrally located NSCLC in medically inoperable patients. The seamless Phase I/II study examined a 5 fraction, dose escalating schedule of SBRT that ranged from 10 to 12 Gy/fraction delivered over 1.5 to 2 weeks in 120 accrued patients from the United States and Canada. Results of this study are published in the Journal of Clinical Oncology.Related StoriesAdult survivors of pediatric brain tumors may experience cognitive, socioeconomic burdensRadiation associated with increased risk of adverse cardiac events in lung cancer patientsStudy shows both IDH-mutant WHO-defined molecular subgroups could benefit from PCV chemoradiotherapyThe MTD was the highest dose level allowed by the protocol, 12.0 Gy per fraction in 5 fractions, and was associated with a 7.2% dose-limiting toxicity (DLT), defined as any treatment-related grade 3 or worse from a list of predefined toxicity types which occurred within the first year. The DLT rate of 7.2% is significantly below the protocol-specified target rate of 20%. Treatment was also associated with high rates of tumor control.”The patients who enrolled into NRG-RTOG 0813 were medically inoperable with early stage lung cancer, mostly elderly and with co-morbidities. The two-year overall survival rates for patients at the two highest doses were 70% which is comparable to patients with peripheral early stage tumors that were treated by SBRT,” stated Andrea Bezjak, MD, of the Princess Margaret Cancer Center and the lead author of NRG-RTOG 0813.Two-year rates for the 71 evaluable patients in the 11.5Gy/fr and 12.0Gy/fr cohorts were: local control 89.4% (90% CI:81.6-97.4), 87.9% (90% CI :78.8-97.0); overall survival 67.9% (95%:50.4-80.3), 72.7% (95%:54.1-84.8); progression-free survival 52.2% (95%:35.3-66.6), 54.5% (95%:36.3-69.6).”This trial demonstrated our ability to provide local control and potential for cure in patients with centrally located, node-negative tumors in multiple institutions, while maintaining plan qualities, achieving good patient outcomes, and only allowing modest rates of toxicity,” added Dr. Bezjak.last_img read more

Warning issued by FDA after patient dies following fecal transplant

first_imgBy Sally Robertson, B.Sc.Jun 14 2019Reviewed by Kate Anderton, B.Sc. (Editor)A warning from the U.S Food and Drug Administration (FDA) was issued yesterday after a patient died due to receiving a fecal transplant that contained drug-resistant bacteria. Such transplants are carried out to treat the infection Clostridium difficile (C. difficile) in patients who have failed to respond to standard treatments.Kateryna Kon | ShutterstockRecurrent C. difficile infections are caused by overgrowth of the microbe, which occurs when the normal composition of the gut microbiome becomes disrupted (dysbiosis) by the administration of antibiotics. Typically, the treatment approach is the use of long-term antibiotics. However, recurrence is common and the infection can be debilitating and lead to significantly reduced quality of life and poor health.Fecal transplants provide an alternative to antibioticsA fecal transplant involves slightly processed feces from a healthy person being transferred to the infected person’s gut to introduce beneficial or “friendly” bacteria. The procedure is intended to restore a diverse and stable gut microbiome that is in keeping with what would be considered a healthy bowel.A fecal transplant provides a more favorable combination of microbial species and strains that complements and replaces a microbiome that has become imbalanced. This restores stability, with the resulting microbiome comprised of all the necessary microorganisms.The only currently approved application of fecal transfer is in the treatment of recurrent C.difficile that continues after standard antibiotic treatment has been used. When the fecal transplant is used, relapse rates are significantly reduced.How do fecal transplants help patients overcome C. difficile infections?The gut microbiota is become increasingly important to researchers who have been discovering more and more about how it functions and contributes to bodily health.A disturbed gut microbiome can contribute to a number of chronic gut disorders and metabolic conditions such as diabetes and obesity. In this context, fecal transfer has emerged as promising approach to restoring a healthy gut microbiome in order to treat diseases of the gut. Evidence has previously demonstrated absolute efficacy when the approach is used to treat recurrent C. difficile.However, there are still questions surrounding the issues of safety and best practice. As interest in the benefits of fecal transplant grows, the potential need for better regulation is being brought to the fore.The FDA reportThe FDA reports that two adult patients with compromised immune systems who had transplants from the same donor became heavily infected with Escherichia coli (E.coli) that produces enzymes called extended-spectrum beta-lactamase (ESBL).Bacteria that produce ESBLs are resistant to many antibiotics including penicillin and cephalosporin. The ESBLs most commonly produced by E.coli are called CTX-M enzymes. When E.coli produces ESBLs, urinary tract infections develop that can lead to more serious infections such as septicemia, which can be fatal.When E.coli produces ESBLs and is therefore resistant to drugs, the infection becomes much more difficult to treat.The FDA says the stool was not checked for the presence of drug-resistant bacteria before the procedure. This only happened once the patients became ill, when a stored sample was tested and found to contain the resistant E.coli that had infected both patients.The failing in procedure has triggered the FDA to state that all potential donors must be screened from now on with questions and stool tests for drug-resistant bacteria.According to the Centers for Disease Control and Prevention (CDC), C. difficile causes almost half a million illnesses annually and can affect all age groups. The CDC also refers to antibiotic resistance as one of the largest public health threats we face today.One report by the CDC found that in the U.S., at least two million individuals acquire drug-resistant infections, which results in death in at least 23,000 cases.last_img read more

Portable device attached to smartphone can diagnose eye disease remotely

first_imgBy Angela Betsaida B. Laguipo, BSNJun 26 2019A portable device attached to a smartphone can help capture precise images of the retina to diagnose eye disease. The new method by a startup company, Phelcom Technologies, is a lower cost tool that can help doctors diagnose remotely, through telemedicine.The FAPESP’s Innovative Research in Small Business Program (PIPE) granted funding and support for Phelcom in 2016. With the grant, the team needed to develop a prototype, which has recently won funding for manufacture and commercialization of the device. Aside from the grant, the Albert Einstein Jewish-Brazilian Charitable Society (SBIBAE) has invested in Phelcom. Phelcom Eyer An app operating the optical device sends images of the retina over the internet to Eyer Cloud, which stores and manages patient files. Image Credit: Phelcom Technologies The device, called Eyer, is designed to light up and visualize the retina. It is connected to a smartphone’s camera. An application sends the captured images over the internet via the Eyer Cloud, which stores the patient files. The ophthalmologist can view the images remotely through the cloud by accessing the patient files.Due to lack of internet connection in some areas across the globe, the images are kept in the smartphone app and sent to the cloud when an internet connection, either Wi-Fi or 4G network is available. Help diagnose retinal eye diseasesThe new device can help diagnose eye diseases, particularly those affecting the retina. The retina is the light-sensing tissue found in the back of the eye. One of its roles is to relay images to the brain.Back-of-the-eye or fundus eye diseases include conditions such as Stargardt’s disease, macular degeneration, retinal tear, diabetic retinopathy and retinal detachment, among others. Stargardt’s disease refer to a group of inherited diseases that affects the light-sensitive cells in the retina to deteriorate. Macular degeneration is a condition where the center of the retina deteriorates, leading to blurred central vision or a blind spot. Retinal tear happens when the vitreous, or gel-like substance in the center of the eye shrinks, pulling the thin layer of tissue lining in the retina, causing a tissue break. Diabetic retinopathy can cause blindness in people with diabetes. It happens when the blood sugar shoots up, causing damage to the blood vessels supplying the retina.The Eyer ProjectRelated StoriesEarly clinical trial of new treatment for severe dry eye disease shows promising resultsDeveloping imaging techniques for early detection of eye and brain diseasesProtein found in the eye can protect against diabetic retinopathyIn March, Phelcom established its São Carlos factory after getting a certification from the National Health Surveillance Agency (ANVISA) and the National Institute of Metrology, Quality and Technology (INMETRO).The factory manufactures 30 units a month but is projected to reach about 100 units by the end of 2019. The device is priced at $5,000, accompanied by a high-quality smartphone. The device is way cheaper than conventional equipment. The currently-used ophthalmoscope device has to be connected to a computer to capture images and it costs around $30,000.  “We invested significantly in optics and in design. One challenge was producing a portable version of a device that is typically very large. Another was enabling nonmydriatic operation so that high-quality images of the retina can be captured without the need for pupil dilation,” José Augusto Stuchi, Phelcom CEO, said in a statement.The Eyer CloudThe company has also developed the Eyer Cloud, an innovation designed to store and manage all the data, including patient information and retinal images, acquired in the diagnostic test. The software works by organizing data, so doctors can remotely access for diagnosis.In contrast, current equipment used today needs to be attached to a computer. The Eyer is portable, easier to use, and more accessible. To set up the Eyer and its cloud, the user should create an account, where the images can be automatically saved.The researchers assured that all data are kept private and confidential. Also, they worked on making the transmitting of images from the device to the cloud faster, so doctors can access the images regardless of the device’s location.The device uses telemedicine, since a licensed or trained technician uses the device to capture the images and sends the photos to the cloud. Meanwhile, an ophthalmologist can visualize and analyze the photos in another location. The process makes diagnosing faster and more convenient.At present, the company plans to establish a partnership with ophthalmologists to develop a part of the system responsible for reporting. For doctors, the planned payment is by a monthly subscription and each report will roughly cost about $5 to $10.Artificial intelligenceAside from the cloud, the team is working on artificial intelligence to help in finding patterns, detecting diabetic retinopathy. The medical reports will be placed in a database, where the computer uses AI to find patterns linked to retinal diseases.A software, approved by the U.S. Food and Drug Administration (FDA), called IDx-DR, utilizes AI to examine eye images captured by a retinal camera. These images will be analyzed to detect diabetic retinopathy, potentially diagnosing the condition early to prevent blindness.The company has more than 10,000 images of the retina and projects about 50,000 patients next year. They plan to have the largest database across the globe. Source:http://pesquisaparainovacao.fapesp.br/portable_device_can_be_used_to_diagnose_eye_disease_remotely/1074last_img read more

In Ivory Coast drone academy offers youth the chance to soar

“Using helicopters is expensive, and on foot, you have to send out teams to areas which can be difficult to reach, which can create problems.”Immediate cost savingsThe financial savings are undeniable: the cost of purchasing a helicopter is around 500,000 euros, with each one hour flight costing another 1,200 euros.A drone, however, costs between 2,000 and 100,000 euros to buy, its upkeep is simple and flight costs are negligible.The company is hoping to improve its quality of service by reducing the average length of power outages—which are still relatively frequent in parts of the country—for its 1.3 million customers in Ivory Coast. “Drones have become my passion,” says Noursely Doumbia, who holds a degree in electronics and is currently learning to pilot drones as part of a pioneering programme in Ivory Coast’s economic capital Abidjan. © 2018 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The training is being offered at a new “drone academy” which has been set up by the Ivorian Electricity Company (CIE) in order to revolutionise the inspection of its infrastructure and ultimately to reduce costs. Although common in Europe, the use of drones is still in its infancy in West Africa although the commercial market for unmanned aircraft is expanding.The aim is for CIE—which is majority-owned by France’s Eranove Group, a key provider of water and electricity in West Africa—to train around 20 local pilots to inspect its high-voltage lines which criss-cross the country, stretching more than 25,000 kilometres (15,500 miles). “We have a lot of problems with vegetation, we need to clear it all the time and it’s difficult because it’s all across the whole country,” explains Benjamin Mathon, a pilot who is in charge of CIE’s drone and youth training programme.Dirt tracks that are impassable following heavy rain, widespread areas of lush tropical vegetation and a patchy road network often conspire to make access to electricity pylons difficult in a country which covers 322,000 square kilometres (124,000 square miles)—nearly two-thirds the area of France.After overflying an area with a drone equipped with cameras and thermal and laser sensors, “we use artificial intelligence programmes which analyse the images for any defects, a rusty bolt on a pylon, a damaged cable,” explains Mathon.Slashing inspection times”The drone allows us to analyse a large number of lines in a short space of time, across great distances,” he says. Citation: In Ivory Coast, ‘drone academy’ offers youth the chance to soar (2018, March 25) retrieved 18 July 2019 from https://phys.org/news/2018-03-ivory-coast-drone-academy-youth.html Explore further And it hopes to do the same for its customer base in neighbouring Ghana, Togo, Benin, Burkina Faso and Mali.Since 2011, following a decade of political and military crisis, Ivory Coast has invested heavily in rebuilding its electricity grid, with the authorities planning to plough another 16 billion euros into the sector by 2030.”The electricity sector is evolving very fast, we must adopt new technologies and innovation,” said Kakou who says the company has already invested in electronic payment schemes and solar energy.Window on tomorrowBut the drone academy is not just serving the electricity sector: it is open to any business in West Africa which could benefit from the technology, from farming to mining, says Paul Ginies, director of the Centre for Electrical Professions, CIE’s training division.”These new professions provide a way in for young people,” he says. “I’m sure that young Africans are going to grab hold of this and surprise us by developing applications which we have not thought of. It’s their generation.”Alice Kouadio, another trainee pilot from the first group of students, has no doubt.”The world is a drone, it’s the promise of tomorrow.” The Ivorian Electricity Company (CIE) is using drones to revolutionise the inspection of its infrastructure Cameroon startup launches drones for global market Not only do students learn how to fly drones, as well as how to assemble and repair them, but are they also trained to use different software packages for analysing the images and resulting data, as well as geolocalisation and mapping.”This is a major technological leap forward for CIE” and its 4,500 employees, says CIE Director General Dominique Kakou. The drones enable CIE to “to inspect our infrastructure and ensure its safety in a much more pinpointed way, and also to optimise our costs and expenses,” he says. Before now, all inspections were done by helicopter or by teams on the ground, Mathon explains. Until now, inspections of Ivory Coast’s electricity network have been done by helicopter or by teams on the ground Students at CIE’s academy are taught how to assemble and maintain drones as well as learning to pilot the unmanned aircraft read more

Senegal launches African cybersecurity school

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Senegal on Tuesday inaugurated a cyber-security school to strengthen West Africa’s defences against computer hackers and use of the internet for terror funding and propaganda. Students of the National School of Administration walk near the banner announcing the creation of a National School of Cybersecurity in Dakar on November 6, 2018 Explore further Citation: Senegal launches African ‘cyber-security’ school (2018, November 6) retrieved 17 July 2019 from https://phys.org/news/2018-11-senegal-african-cyber-security-school.htmlcenter_img Africa needs to beef up cyber security urgently: experts Senegalese Foreign Minister Sidiki Kaba and French counterpart Jean-Yves Le Drian gave the ceremonial start to the National Cyber-Security School (ENVR) on the sidelines of an annual regional security conference in Dakar.The school will provide training in combating cyber-crime for the security services, judiciary and private enterprises.Backed by France, it will have a “regional vocational role” in helping other countries in West Africa, French officials said.The ENVR, which was proposed at last year’s security conference, will initially be based in Dakar at the National School of Administration (ENA) before moving to Diamnadio, a new town being built around 30 kilometres (20 miles) from the capital. © 2018 AFPlast_img read more